I would definitely agree with the opinions here. Qsnaps are great, but they dont give you a ton of place to put the extra fabric. (you can bunch it up and clamp it to the side, but yeah, the bigger the project, the heavier thatll be!) Scroll frames are definitely nice for larger projects because you can roll the pattern and fabric as you go and its all kept nice and neat. And if you do want to change out the design, you can take off the scroll rods its on and put in another pair, storing the piece on the rods for the time being.
That being said, I still love Q-snaps. The tension they give you on the fabric is great. I use these for all my smaller/medium pieces. Even the 8x8 frame is nice. I dont have a hoop so I havent worked with one of those in quite some time, but I personally didnt care for how they crush the stitches. (My hoop snapped - I just replaced it with the small qsnap.) Though, obviously if you have a really small piece you need a tiny hoop - or do it in hand. I know a lot of people do the big pieces like that too.
I like q-snap because they give me the drum tight fabric feeling I had with the hoop but they dont leave any marks or stretch the fabric. I also noticed that at the beginning they where a little hard to take off but after a short time of usage they eventually softened up a little.
I use Q-snaps... ever since I first came across them a few years ago, thats all Ive used since. They come in several different sizes and some of them even have an extension kit to make them bigger. I will never use a hoop again. If you leave the clamps on the project all the time like I do, then they will start to become looser. When this happens I cut strips of felt and put it between the project and the clamps. This protects your stitches some as well as makes the clamps tighter on your project!